Journal of Natural Remedies

S. S. Jalalpure , M. B. Patil , K. R. Alagawadi

Abstract

Objective: To screen the wound healing activity of different extracts of galls of Quercus infectoria on incision, excision and dead space (granulation) wound models in albino rats. Materials and method: Crude aqueous extract of Quercus infectoria galls and its three different crude fractions, petroleum ether (40°-60°C), solvent ether, ethyl acetate were tested for various preliminary phytoconstituents and were screened at dose of 100mg/kg for wound healing properties in incision, excision and dead space (granulation) wound models in albino rats. Results: Tannins, flavonoids, steroids and carbohydrates were found to be present in aqueous extract and its various fractions of galls of Quercus infectoria. In resutured incision wound models aqueous extract and its fractions showed significant (P<0.01) breaking strength compared to control. In excision wound parameters the aqueous extract promotes better wound healing (96.36%) compared to control and organic fractions. Breaking strength of the grass pith induced granuloma studies the results show significant (P<0.01) activity in case of aqueous extract along with solvent ether fraction. Conclusion: From the results obtained, it can be observed that aqueous extract and its fractions of galls of Quercus infectoria have significant wound healing property. Also it can be concluded that flavonoids may be responsible for wound healing activity.

Keywords

Quercus infectoria, Wound-healing, Aqueous Extract, Soxhlet Extraction

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Shiv Kumar , K. R. Alagawadi

Abstract

The present study was aimed to screen the possible antiobesity effects of ethanol extract of Alpinia galanga rhizomes in cafeteria diet fed obese rats. Obesity was induced in albino rats by feeding cafeteria diet daily for 6 weeks in addition to normal diet. The ethanol extract of rhizomes was administered at a daily dose of 500 mg/kg orally for 6 weeks. Body weight and food intake was measured initially and then every week thereafter. On day 42, serum glucose, lipids and leptin levels were estimated and then the weight of liver and parametrial adipose tissues was determined. The liver triglyceride content was estimated. The in vitro pancreatic lipase inhibitory activity of the extract was also determined. The extract produced inhibition of increase in body weight, energy intake and parametrial adipose tissue weight induced by cafeteria diet. The extract significantly reduced serum lipid and leptin levels, which were elevated by feeding cafeteria diet. In addition, the extract significantly inhibited the increase in liver weight and accumulation of hepatic triglycerides. The extract also produced dose dependent inhibition of in vitro pancreatic lipase activity. The present study concludes that, ethanol extract of Alpinia galanga rhizomes is useful for treatment of cafeteria diet induced obesity in rats.

Keywords

Alpinia galanga, Body Weight, Cafeteria Diet, Antiobesity, Pancreatic Lipase, Sibutramine, Leptin

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M. S. Ganachari , Shiv Kumar , K. R. Alagawadi

Abstract

Objective: To evaluate the effect of Ziziphus jujuba leaves extract in cafeteria diet and atherogenic diet induced obesity. Methods: Obesity was induced in albino rats by feeding cafeteria diet/atherogenic diet daily for 40 days in addition to normal diet ad libitum. Body weight was measured on day 1 and then on alternate days for 40 days. Daily food intake for group of 6 rats was assessed. Serum glucose and lipid levels and internal organs and fat pad weight analysis was carried out on day 41. Results: The Z. jujuba leaves extract treatment caused significant reduction in body weight, daily food intake, serum glucose and lipid levels, internal organs and fat pad weights in cafeteria and atherogenic diet fed rats when compared with control group of rats. Conclusion: The results of the present study conclude that alcoholic extract of Z. jujuba leaves showed anti-obese property by decreasing the body weight, food intake, serum glucose and lipid levels and internal organs and fat pad weights in dietary obese rats. The effect produced was comparable with that produced by standard anti-obese drug, Sibutramine.

Keywords

Anti-obese, Atherogenic Diet, Cafeteria Diet, Obesity, Sibutramine, Ziziphus jujuba

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